Category: Science (page 1 of 17)

Methods Section of a Research Paper: What is it good for? Absolutely Everything.

I love a well-written methods section in a research communication. There, I said it. And as a peer reviewer, I often go to the methods in the manuscript under review in order to understand both the experiments that authors have designed and performed, and the rationale behind the flow and organization of different experiments, each yielding a separate piece of the overall puzzle in form of data. But I didn’t start out this way; this is the story of my evolution, as well as the woeful tale of a long-held (and recently re-encountered, in a high impact journal, no less) annoyance—poorly or inadequately written, incomplete methods.

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Review Unto Others, As You Would Have Others Review Unto You: my Golden Rule for Scientific Manuscripts

Finding—more like, eking out!—time from within a back-breaking work schedule, I recently managed to review back-to-back four manuscripts for publication in diverse journals. The topics in these papers touched my work only marginally, in that they belonged to the broad areas of microbiology, antibodies and immunodiagnostics. A chance remark by a professional friend—”Your reviews are impressively long and detailed…“—got me thinking about my overall experience reviewing scientific manuscripts. “Long and detailed” is probably why it takes me a considerable time and effort to go through the paper, occasionally check the references, and note down my thoughts in the margin, either on paper (i.e. on a print-out), or electronically (annotating the manuscript PDF, my preferred mode). Not unknown to anyone who is familiar with the process of scientific publishing and the world of biomedical journals, Peer Review is a mechanism that attracts a significant amount of controversy. So why do I keep investing the time and effort towards it? More after the fold.

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Nature Publishing Group dabbling in Homeopathy is a loss of opportunity for good pharmacognostic research

This morning, I was alerted to the latest homeopathy shenanigan via the Forbes column of Dr. Steven Salzberg. (COI statement: I don’t know Dr. Salzberg personally, but I follow his columns, and he is a faculty member at my institution—albeit in a discipline not directly related to mine.) At the heart of it is yet another bog-standard ridiculous “study” purporting to show “clinical effect” of homeopathy, despite the preponderant evidence that homeopathy does not work. What makes this instance special enough for me to take time out from my over-burdened work schedule? The fact that it was published in Scientific Reports from the—wait for it!—Nature Publishing Group. Yes, THAT Nature.

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In Which I Discover My First Homeopathic Remedy

It has been a while since I last posted on homeopathy. Frankly speaking, having written about it quite a bit, I have grown kinda tired of the utterly unscientific, nonsensical nature of homeopathy, and foolishness of its relentless proponents. However, a few days ago on Twitter, my attention was brought to a whole new level of ridiculousness in this quackery modality, and I found it concerning anew because of what it implies for the hapless, gullible and vulnerable patients desperately seeking medical care. Today’s short post touches on this.

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Making pseudoscience of homeopathy immune from criticism does not serve public weal

A physician friend alerted me the other day about a strange new official proclamation from the Government of India (GoI). With a long history of uncritical friendliness (as well as State-sponsorship) towards various alternative medicine modalities, GoI —specifically, the ministry in charge of altmed, the Ministry of AYUSH (Ayurveda, Yoga, Unani, Siddha & Homeopathy) in this case— announced that a “high level committee” has been set up to “deal with issues” related to “false propaganda against homeopathy”.

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Evolution of Sodium Benzoate Chemophobia Promoted by Panera Bread, from ‘complex structure’ to ‘present in fireworks’

Oh the humanity of it all! Back in November I had written about the decidedly weird chemophobia around Sodium Benzoate being promoted by Panera Bread, one of my favorite bakery and soup-salad places in the US. As I wrote, my wife and I love to eat there, but its anti-science, pro-pseudoscience stance on this issue was profoundly disappointing. Well, three-quarters of a year later, it turns out they are still assiduously at it.

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Worrisome Trends in Anti-Science Push Targeting School Children in the US

This morning I came across an unsettling BuzzFeed report by Zahra Hirji (@Zhirji28 on Twitter) on how climate change denialism is being peddled to school teachers in the US.  Reports Zahra:

Teachers nationwide are being targeted in a campaign to spread bogus information about climate change…

Packages holding a cover letter, a 135-page book, and an 11-minute DVD, all falsely claiming that there is no scientific consensus on man-made climate change, started arriving in teacher mailboxes in March. The mailings were sent to more than 300,000 teachers, according to the group behind the campaign, the Heartland Institute.

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Asparagus, Odorants and SNPees; with a hat tip to SciAm’s Steve Mirsky

This morning I chanced upon, via that inexhaustible font of newsly tidbits otherwise known as Twitter, this fresh Scientific American essay by veteran science writer Steve Mirsky expounding upon a commonplace phenomenon that has been a lasting mystery as well as, interestingly, a source of conversation around science —the strong smell in urine following the consumption of Asparagus, that well-loved, delectable vegetable of Le Printemps known to mankind since 3000 BCE.

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Arnica Extract Changes Gene Expression in Extracellular Matrix? Probably. Does Homeopathic Arnica? Haha, No!

ResearchBlogging.org

A paper published last month in PLOS One by a group of investigators from the University of Verona in Italy states that Arnica montana Stimulates Extracellular Matrix Gene Expression in a Macrophage Cell Line Differentiated to Wound-Healing Phenotype. Given my abiding interest in pharmacognosy and ethnobotany, I was suitably intrigued because the extract derived from Arnica montana, a European flowering plant of the sunflower family, is likely to be biologically active due to the presence of certain sesquiterpene lactones (same class of substances as present in the plant-derived anti-malarial Artemisinin), the plant metabolite flavonoids (substances with some in vitro anti-oxidant and anti-inflammatory activity), and derivatives of thymol (phenolic substance with antimicrobial action). Like many bioactive phytopharmaceutical substances, Helenalins, the sesquiterpene lactones and their fatty acyl esters in Arnica montana, are toxic in high concentrations, but have anti-inflammatory properties via its inhibition of the transcription factor NFkB.

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I Love Panera Bread, But Yikes! Must They Peddle This Daft Chemophobia?

I love the café/bakery eatery chain Panera Bread. Ever since I was introduced to them in 2003, my wife and I have frequented this establishment in many different cities of the US, finding with delight that our trust in their food quality and quantity has not been misplaced. We love their menu items, soups and sandwiches – even some of their seasonal salad offerings (and that’s saying something, because neither of us is a very salad-y person). My wife is particularly keen on their Chai Tea Latté. Their bakery is excellent, not to mention the delicious breads they make, which can be bought separately. So imagine my consternation, when on a recent visit, I discovered that they appear to be peddling some weapons-grade bullshit about chemicals and additives in food.

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