ResearchBlogging.org

I hope by now you, my gentle reader(s), are familiar with the story of diabetes, insulin resistance and their link with chronic inflammation. Let me emphasize once more. Inflammation per se is not a bad thing; it is an essential process in the immune defence of the body. Whenever there is an invasion of a tissue, internal or external, by a foreign substance – such as a pathogen, the inflammatory process, initiated by signals from the primary defence cells in the tissue (such as Macrophages), calls in reinforcements from bone marrow derived immune cells, the secondary defence system of the body – in form of leukocytes (a.k.a. White Blood Cells/WBCs; e.g. neutrophils, T- and B-lymphocytes, monocytes, and sometimes basophils and eosinophils) and/or mast cells, from blood into the tissue. These defence cells communicate with each other and perform their action by releasing chemical substances known as cytokines and chemokines, that act as messengers.

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